Nutrition / Obesity / Physical activity

Nutrition / Obesity / Physical activity

Prevalence of Creatine Deficiency Syndromes and Genetic Variability in Creatine Metabolism in Children with Autism Spectrum Disorder - A Pilot Study

Lead principal investigator
Andreas Schulze, MD, PhD - University of Toronto
Study period

Apr 2010 – Mar 2012

Determine prevalence of CDS in children with autism and assess the interaction of genotypic variability of the three known genes involved in creatine metabolism with the autism phenotype.

Final N: N=455 subjects enrolled (age >2 years)

Collaborators:

  • Anne Tsai, MD - University of Colorado
  • Margaret Bauman, MD - Lurie Center

Maternal Cholesterol and Autism

Lead principal investigator
Jean-Baptiste Roullet, PhD - Oregon Health & Science University
Study period

Sep 2010 – Aug 2012

Characterize maternal sterol metabolism in mothers of children with autism in part to evaluate the rationale of maternal cholesterol supplementation during pregnancy to reduce the risk of having an autistic child

Markers of Iron Status and Metabolism in Children with Autism Spectrum Disorders

Lead principal investigator
Ann Reynolds, MD - University of Colorado
Study period

Sep 2009 – Aug 2012

Children with autism spectrum disorders (ASDs) often have food selectivity and restricted diets, putting them at risk for nutritional deficiencies. Previous studies have demonstrated a high prevalence of iron deficiency (ID) in children with ASDs living in Wales, Canada, and Turkey. The objectives of this study were to determine the prevalence of ID and the adequacy of iron intake in children with ASD in the United States.

Iron Treatment of Sleep Disorders in Children with Autism Spectrum Disorder

Lead principal investigator
Ann Reynolds, MD, University of Colorado - Denver
Study period

Apr 2012 – Apr 2014

The AIR-P Iron & Sleep study was a 2 year study designed to evaluate the effect of iron supplementation on restless legs syndrome and periodic limb movement of sleep. A total of 20 children (ages 3-10) were enrolled and randomized across four ATN centers.

Diet and Nutrition in Children with ASDs: An ATN Collaborative Study

Lead principal investigator
Susan Hyman, MD, University of Rochester
Study period

Sep 2008 – Aug 2011

The impact of abnormal feeding behaviors reported for children with autism spectrum disorders (ASDs) on their nutritional status is unknown. We compared nutrient intake from food consumed by children with and without ASD and examined nutrient deficiency and excess.

Bone Mineral Density in Children with Autism Spectrum Disorders

Lead principal investigator
Ann Neumeyer, MD - Lurie Center for Autism
Study period

Sep 2009 – Aug 2011

We determined whether bone mineral density (BMD) is lower in boys with autism spectrum disorders (ASD) than controls, and also assessed variables that may affect BMD in ASD. BMD was measured using dual energy X-ray absorptiometry (DXA) in 18 boys with ASD and 19 controls 8–14 years old. Boys with ASD had lower BMD Z-scores at the spine, hip and femoral neck, and differences at the hip and femoral neck persisted after controlling for maturity and BMI. Vitamin D intake from food and in serum were lower in ASD subjects, as was exercise activity. We conclude that BMD is lower in peripubertal boys with ASD and may be associated with impaired vitamin D status and lower exercise activity.

Study of Oxytocin in ASD to Improve Reciprocal Social Behaviors

Lead principal investigator
Ann Neumeyer, MD - Massachusetts General Hospital for Children
Study period

Jun 2016 – Aug 2017

The SOARS-B trial (Study of Oxytocin in ASD to improve Reciprocal Social Behaviors) is a pivotal randomized, placebo-controlled investigation of intranasal oxytocin in the treatment of social dysfunction in children and adolescents with ASD that is funded by the NIH.

Physical Exercise to Reduce Anxiety in Underserved Children with ASD

Lead principal investigator
Jean Gehricke, PhD – University of California, Irvine
Study period

Jun 2015 – Aug 2017

This research proposal will examine the feasibility and efficacy of a physical exercise intervention to reduce anxiety in children from underserved families. The physical exercise program is designed to incorporate the new key guidelines for physical exercise in children from the Centers for Disease Control.